October 22, 2024
United States Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, DC 20549
| Attention: | Ibolya Ignat Angela Connell Tamika Sheppard Suzanne Hayes |
| Re: | Septerna, Inc. (the “Registrant”) |
Registration Statement on Form S-1 (File No. 333-282469)
Request for Acceleration
Ladies and Gentlemen:
Pursuant to Rule 460 of the General Rules and Regulations under the Securities Act of 1933, as amended, we wish to advise that between October 21, 2024 and the date hereof, approximately 1,100 copies of the Preliminary Prospectus, dated October 21, 2024, were distributed to prospective underwriters, institutional investors and prospective dealers in connection with the above-captioned Registration Statement, as amended.
We wish to advise you that the participating underwriters have informed us that they have complied and will continue to comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.
We hereby join in the request of the Registrant that the effectiveness of the above-captioned Registration Statement, as amended, be accelerated to 4:00 p.m. Eastern Time, on Thursday, October 24, 2024 or as soon thereafter as practicable.
[signature page follows]
| Very truly yours, | ||
| J.P. MORGAN SECURITIES LLC TD SECURITIES (USA) LLC CANTOR FITZGERALD & CO. WELLS FARGO SECURITIES, LLC As representatives of the Underwriters | ||
| J.P. MORGAN SECURITIES LLC | ||
| By: | /s/ Benjamin Burdett | |
| Name: | Benjamin Burdett | |
| Title: | Managing Director, Head of HC ECM | |
| TD SECURITIES (USA) LLC | ||
| By: | /s/ Bill Follis | |
| Name: | Bill Follis | |
| Title: | Managing Director | |
| CANTOR FITZGERALD & CO. | ||
| By: | /s/ Sage Kelly | |
| Name: | Sage Kelly | |
| Title: | Global Head of Investment Banking | |
| WELLS FARGO SECURITIES, LLC | ||
| By: | /s/ Ryan Haney | |
| Name: | Ryan Haney | |
| Title: | Executive Director | |
[Signature Page to Acceleration Request Letter]